01 · Polynucleotides
What are polynucleotides?
Polynucleotides (PN) are chains of nucleotides used in some injectable products intended for skin quality. They are not the same material as hyaluronic acid (HA) and should not automatically be grouped as dermal fillers.
Research suggests possible benefits for wrinkles, texture, and elasticity, but the evidence remains limited. A systematic review found only nine studies with 219 participants; study quality was low to moderate and methods varied. It therefore cannot establish a best brand, an ideal protocol, or the same outcome for everyone.
02 · Profhilo
What is Profhilo?
Profhilo is an injectable gel from IBSA containing high- and low-molecular-weight hyaluronic acid. The manufacturer's instructions describe it as a hyaluronic-acid product without chemical cross-linking, for intradermal use according to its approved instructions.
It is generally selected with skin quality in mind rather than to shape a specific facial feature like a volumising filler. This does not make it risk-free or suitable for everyone. Systematic reviews of injectable HA for skin quality are promising but still call for larger randomised trials; outcomes vary by person.
03 · Product groups
How are the clinic's injectable products grouped?
This table includes only names confirmed through manufacturer information, instructions for use, or an official registration. Groups are based on principal material and purpose, not only the marketing term “skin booster.”
| Group | Verified products on the current list | What the group tells us |
|---|---|---|
| Polynucleotides (PN) | REJURAN HEALER 2ML, REJURAN I 1ML, REJURAN S 1ML; HP VITARAN; Plinest, Plinest Eye, Plinest Hair | PN is the principal material. Product versions and treatment areas are not interchangeable and must follow the relevant instructions. |
| HA for skin quality | Profhilo; Ejal 40; Cytocare 532; Belotero Revive | HA products focused on hydration or skin quality. Belotero Revive also contains glycerol and is described by its manufacturer as a dermal filler, but its purpose is skin quality rather than substantial volumising. |
| Mixed mesotherapy formulas | NCTF 135HA | Free HA combined with vitamins, amino acids, co-enzymes, nucleosides, minerals, and other ingredients according to FILLMED. It is not an HA-only product. |
| Dermal fillers | Restylane range (specific model to be confirmed before treatment) | Cross-linked HA gels are selected according to the approved purpose, treatment area, and properties of each model. The brand name alone does not identify the appropriate model. |
| CaHA biostimulator / filler | Radiesse + Lidocaine | Radiesse (+) is an injectable implant containing calcium hydroxylapatite (CaHA) in a gel carrier with lidocaine. It is not a PN product or an HA skin booster. |
| Scalp products | Plinest Hair; INNO-TDS HAIR VITAL; INNO-TDS HAIR LOSS CONTROL | This is a separate hair-and-scalp category. Plinest Hair is PN-based; the INNO-TDS products are professional multi-ingredient formulas. The cause of hair loss needs assessment before treatment is chosen. |
Shop products are separate: skincare and haircare used at home are not injectable products and are not included in this table.
04 · Comparison
How do Rejuran, HP VITARAN, and Profhilo differ?
- Rejuran is a PN product family from PharmaResearch. HEALER, I, and S are different versions; model selection should follow product instructions and medical assessment.
- HP VITARAN is a PN product from BR PHARM. The manufacturer confirms polynucleotide sodium as the principal material in HP VITARAN. Specific claims about other versions should wait until their exact labels are confirmed.
- Profhilo is an HA product from IBSA containing high- and low-molecular-weight hyaluronic acid; it is not a PN product.
This review found no robust head-to-head evidence showing that one of these brands is best for everyone. The appropriate choice depends on the concern, treatment area, health history, risk assessment, and goals.
05 · Terminology
How is a skin booster different from a dermal filler?
“Skin booster” is a broad descriptive term that can cover different products intended for hydration or skin quality. A dermal filler is a gel selected to fill, shape, or support tissue according to the product's properties and approved instructions.
The categories can overlap in regulatory or marketing language: for example, Merz describes Belotero Revive as a dermal filler for skin quality. Always confirm the exact product, composition, cross-linking, intended use, and treatment area rather than relying on the label “skin booster” alone.
06 · Eye area
Choosing care for the eye area
Dark circles, hollowness, fine lines, dryness, puffiness, and skin laxity do not always have the same cause. A treatment suited to one concern may be inappropriate for another. Assessment should consider facial anatomy, skin quality, tendency to swelling, previous procedures, and health history.
Options may range from gentle skincare and sun protection to device-based treatments or carefully selected injectables. Proximity to the eyes and blood vessels requires particular attention to risk. No treatment can guarantee a specific result.
07 · Facials
How do I choose a facial?
Start with your skin's current condition and one or two realistic goals. Dry or sensitive skin may be better suited to a gentle treatment focused on hydration and comfort. For dullness or uneven texture, renewal options can be discussed if the skin can tolerate them.
Mention active irritation, infection, recent procedures, medication, and important upcoming events. Ask what the facial involves, which reactions are common, how much recovery time to expect, and what home routine is recommended. A more expensive or intensive treatment is not automatically better.
08 · Safety & aftercare
What to know before and after injections
Before your appointment
- Share your medical history, allergies, previous injectable treatments, medicines, and supplements. Do not stop prescribed medicine unless the prescriber advises it.
- Tell the clinic about pregnancy or breastfeeding, active infection, inflamed skin, dental work, or illness near the planned appointment.
- Confirm the exact product name, treatment purpose, common reactions, rare serious risks, and aftercare before consenting.
After your appointment
Mild redness, tenderness, swelling, or bruising can occur after injections. Follow your practitioner's specific instructions because aftercare varies by product and treatment area.
After filler: seek emergency medical care immediately
Seek emergency medical care immediately for any change in vision, unusual pain, skin that becomes pale, white, grey, or blue near the injection site, or symptoms of a stroke. You may also inform the clinic, but do not wait for a reply before seeking help.
Sources
Evidence used for this guide
Sources were reviewed on 18 September 2026. Product information can change; the instructions supplied with the exact clinic stock should always be checked before treatment.
- FDA: Dermal Fillers (Soft Tissue Fillers)
- Systematic review: polynucleotides in aesthetic medicine
- Systematic review: injectable HA and facial skin quality
- IBSA: Profhilo product information
- PharmaResearch: Rejuran product family
- BR PHARM: HP VITARAN product information
- Mastelli: Plinest product family
- FILLMED: NCTF 135HA product information
- Merz: Belotero Revive product information
- Malaysia Medical Device Authority: Cytocare 532 registration
- Vietnam Ministry of Health device dossier: Ejal 40
- Galderma: Restylane instructions for use
- Radiesse (+) Lidocaine instructions for use
- INNOAESTHETICS: Hair Vital and Hair Loss Control